British Air Force Typhoon FGR4s have conducted a mission with France's air force in a combined operation against an underground arms cache in Syrian territory operated by the Daesh militant organization, according to the British defence ministry.
The site, identified by intelligence, was assessed as storing arms and explosives, the release indicated, and was located in mountains just to the north of the ancient city of Palmyra in Syria's central region.
"The RAF jets employed laser-guided Paveway IV weapons to target a several approach shafts leading to the site... early reports suggest the target was engaged successfully," the MoD said.
There was no evidence of any harm to civilians in the attack on Saturday evening and each participating jet returned to base without incident, the MoD added.
The Typhoon fighters were assisted by a Voyager tanker plane.
Daesh - also known as the so-called Islamic State - established militant control over parts of Syria and Iraq until 2019.
"This strike shows our UK leadership, and commitment to work closely with our allies, to eradicate any re-emergence of Daesh and their harmful and extremist ideologies in the region," UK Defence Secretary John Healey said.
UK warplanes have conducted overwatch operations over Syrian airspace to "forestall any attempted resurgence" of the group following its military defeat at the battle of Baghuz in 2019, the ministry said.
"I extend gratitude to every member of British forces involved in this operation for their skill and their courage," the Defence Secretary said. "Including them were numerous UK service members deployed over Christmas and New Year. This action, to remove terrorist threats who threaten our security, shows how British military are always on standby, continuously, keeping Britain secure within its borders and strong abroad."
Last December, the US military conducted what it called a "massive strike" on IS targets in Syria, after an ambush claimed the lives of two American soldiers and a local interpreter in the Palmyra area.
The U.N. estimates Daesh still boasts between 5,000 and 7,000 combatants in Iraq and Syria.